Re: vortec v6
8-9psi is generally a maximum for a stock long block that's originally an NA with 10:1 or so compression ratio, regardless of the engine size or configuration. It's about the fuelling and knock, (detonation), risk.
Others will have experience that they'll quote you hopefully but no way should you chance it above 8-9psi, unmodified.
The SyTy block has a heat treated crank, (I think, since mine rings like a bell unlike standard cast iron which just has a dead note when struck), spheroidal graphite main caps and hyper-eutectic pistons to give tight clearance because of low expansion at high temperature.
I would strip the block completely and replace all of the rotating assembly if possible. The heads should be fine though. I'm converting my LB4's to Vortec's myself.