Whatcha gonna drop it in?
IF a syty is the answer yes it will work.
Main problem is you won't be able to run much boost due to the high compression.
Some people say the late model balance shaft block is weaker. Probably is but who knows what the limit for it is. They are smooth though.
If you want to run any kind of boost you would have to put in low compression piston and good gaskets. Also the heads would have to be drilled and intake manifold welded up.