Re: engine transplant
A lot of it would depend on how emission friendly your state is, in your area
Leadfoot did it, using the Syclone harness but later decided to use the 2002 truck harness, so he could get his dash to work, and it allowed him to update to the 4L60e tranny.
98 and newer S10's get several of the dash readings from the class 2 data buss, using the SyTy harness and ECM would not allow them to work.
You're also opening a new bag of worms, with it originaly being a 2.2, which means its a 2WD, it would also need differant fram mounts..